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Friday, November 19. 2010

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Friday, November 19. 2010

Heart Stem cell Treatment Trials at Cedars Sinai Medical Center.

 

Stem cell treatment of diseases affecting millions of Americans is gaining traction in the US. Below you can see excerpts from articles on the internet on clinical trials with stem cells to treat Myocardial infarctions, blindness, and even Parkinson’s disease.

The next logical extension would be treating aged and damaged skin via your own autologous stem cells. The field is still in its infancy and there is a lot we still need to learn.

These are truly exciting times and I feel privileged to be part of it.

A. David Rahimi, MD, FAAD, FAACS.

 

 

Heart Stem Cell Trial at Cedars Sinai – Patient’s Own Cells Injected to Reverse Heart Attack Damage

Finally the work and benefits of stem cells are beginning to evolve around us.  The patient had a heart attack, had permanent damage and by injecting his own stem cells the efforts of this procedure will hopefully reverse the damage and scarring done by the attack.  The program is under trial at Cedars Sinai in Los Angeles.  "Cardio-spheres" are created and can even start beating in the dish.  This was a big decision and we certainly hope it works for him.  BD

Heart failure patient improves after clinical trial – Injection of Cardiac Stem Cells at University of Louisville

The cardiac stem cells injected into the scar tissue were removed from a portion of the upper chamber of Jones’ heart and were sent to Harvard University and Brigham and Women’s Hospital in Boston to grow the cardiac stem cells.   The procedures is fairly simple and minimally invasive as well and it was estimated that he could return to work in a week.  The patient will be monitored over the next 2 years to track his progress. 

In the Los Angeles area we have a similar clinical trial in place at Cedar Sinai Hospital and this is amazing and something I want to make sure I follow as well as this is breakthrough technology for repairing the heart and his condition is improving almost daily. 

 

 

Stem Cells Turn Cloudy Eyes into Clear Eyes

More exciting news on the potential use of stem cells.  The story is from the University of Pittsburgh who has done quite a bit of research with stem cells and the testing now is limited to mice. This could potentially stand to emerge to be an alternative treatment to having a cornea transplantThe next step is testing mice with scars on their corneas. 

In another related story a family made a trip to China for stem cell injections for a child who was going blind and now she can see.  After the 3rd treatment of injections in to her spine, it started working, she could read and now has 20/30 vision.  So far only 10 people had had the treatment with stem cells for the underdeveloped optic nerve.  The entire treatment took 6 weeks.

Michael J. Fox on Parkinson’s Disease and Stem Cells – Oprah and the Daily Show

Michael Fox has written a new book, “Always Looking Up”, great title too by the way and has been appearing on several talk shows to promote the book.  You can visit the Foundation to find out what is being done with a cure/treatment for Parkinson’s Disease at the Foundation Web site. 

The Michael J. Fox Foundation

I have included a couple videos here, first from the Daily Show, and you can clearly see he has not lost his sense of humor, even tackling the question of which is more difficult, the disease or politicians.

What is even more amazing is his appearance on Oprah and the revelations from Dr. Oz on where and when he believes a cure may be here for the disease.  The cure lies in stem cells, but perhaps not the way we have heard stem cells discussed in the past.  The TED convention this year also offered a lot of information on stem cells and the video from the show is well worth watching and will help explain what regenerative medicine is all about.  Cloning stem cells is on the horizon to be part of the cure.  If you haven’t caught up with what’s going on with stem cell research, it’s well worth reading up.  There are women walking around with bladders that have been grown from stem cells, heart valves are grown from stem cells, etc.  If they can bring this technology to cure or better treat Parkinson’s, that would be great for all those who suffer. 

Cloned cells bring hope of therapy for Parkinson’s disease

In the related reading below I went back and captured some of the prior posts I have made about Parkinson’s Disease to include some of the medical devices that are being used for treatment as well.  When you watch and see how the implants are helping, it’s amazing.  One woman was in such a terrible state, she was refined to a wheelchair, and with the device she can function almost pretty normal, and another victim of the disease was able to get a driver’s license, something that had never been possible before.  Between research and development with stem cells and devices, there are great strides being made and helping bring a bit of quality of life to those stricken.  BD 

 

Wednesday, November 17. 2010

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Wednesday, November 17. 2010

Acne Scar Treatment with Stem Cells

 

Why not allow your own stem cells and fat to fill in the acne scars on your face.

Here is a small segment out of an article from Mayo Clinic explaining what stem cells are and what they are capable of doing:

§  Adult stem cells. These stem cells are found in small numbers in most adult tissues, such as bone marrow. Adult stem cells are also found in children and in placentas and umbilical cords. Because of that, a more precise term is somatic stem cell, meaning "of the body." Until recently, it was believed that adult stem cells could only create similar types of cells. For instance, it was thought that stem cells residing in the bone marrow could give rise only to blood cells. However, emerging evidence suggests that adult stem cells may be more versatile than previously thought and able to create unrelated types of cells after all. For instance, bone marrow stem cells may be able to create muscle cells. This research has led to early-stage clinical trials to test usefulness and safety in people.

§  Adult cells altered to have properties of embryonic stem cells (induced pluripotent stem cells). Scientists have successfully transformed regular adult cells into stem cells using a technique called nuclear reprogramming. By altering the genes in the adult cells, researchers can reprogram the cells to act similarly to embryonic stem cells. This new technique may help researchers avoid the controversies that come with embryonic stem cells, and prevent immune system rejection of the new stem cells. But, it's not yet known if altering adult cells will cause adverse effects in humans. Researchers have been able to take regular connective tissue cells and reprogram them to become heart cells. The new heart cells were injected into mice with heart failure, where they improved heart function and survival time.

 

At Forever Young, Inc. we have devised a system where peripheral and fat stem cells are harvested via a sophisticated centrifugation process, concentrated and mixed with your own fat.

The fat and peripheral/fat stem cell are injected via blunt tipped canulas and No-Kor needles under the acne scars. This is followed by either a TCA peel or Mixto CO2 Fraxel (see my procedure section for more details on each of these procedures).

Downtime is about 5 days and several procedures are needed for deep scarring. Prices range from $1500 to $5000 depending on the procedures needed.

I hope to see you for a complimentary consultation.

A. David Rahimi, MD, FAAD,FAACS.

 

 

Thursday, November 11. 2010

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Thursday, November 11. 2010

Stem Cell; what are they and what can they do?

While researching stem cell I came across a section on Mayo clinic’ website that concisely explains what stem cells are, where they can be found, and what are they capable of doing.

Here is the first paragraph and a link:

http://www.mayoclinic.com/health/stem-cells/CA00081

 

What are stem cells?

Stem cells are the body's raw materials — cells from which all other cells with specialized functions are generated. Under the right conditions in the body or a laboratory, stem cells divide to form more cells, called daughter cells. These daughter cells either become new stem cells (self-renewal) or become specialized cells (differentiation) with a more specific function, such as blood cells, brain cells, heart muscle or bone. Stem cells are unique — no other cell in the body has the natural ability to generate new cell types.

Where do stem cells come from?

Researchers have discovered several sources of stem cells:

§  Embryonic stem cells. These stem cells come from embryos that are four to five days old. At this stage, an embryo is called a blastocyst and has about 150 cells. These are pluripotent (ploo-RIP-uh-tunt) stem cells, meaning they can divide into more stem cells or they can specialize and become any type of body cell. Because of this versatility, embryonic stem cells have the highest potential for use to regenerate or repair diseased tissue and organs in people.

§  Adult stem cells. These stem cells are found in small numbers in most adult tissues, such as bone marrow. Adult stem cells are also found in children and in placentas and umbilical cords. Because of that, a more precise term is somatic stem cell, meaning "of the body." Until recently, it was believed that adult stem cells could only create similar types of cells. For instance, it was thought that stem cells residing in the bone marrow could give rise only to blood cells. However, emerging evidence suggests that adult stem cells may be more versatile than previously thought and able to create unrelated types of cells after all. For instance, bone marrow stem cells may be able to create muscle cells. This research has led to early-stage clinical trials to test usefulness and safety in people.

§  Adult cells altered to have properties of embryonic stem cells (induced pluripotent stem cells). Scientists have successfully transformed regular adult cells into stem cells using a technique called nuclear reprogramming. By altering the genes in the adult cells, researchers can reprogram the cells to act similarly to embryonic stem cells. This new technique may help researchers avoid the controversies that come with embryonic stem cells, and prevent immune system rejection of the new stem cells. But, it's not yet known if altering adult cells will cause adverse effects in humans. Researchers have been able to take regular connective tissue cells and reprogram them to become heart cells. The new heart cells were injected into mice with heart failure, where they improved heart function and survival time.

§  Amniotic fluid stem cells. Researchers have also discovered stem cells in amniotic fluid. Amniotic fluid fills the sac that surrounds and protects a developing fetus in the uterus. Researchers have identified stem cells in samples of amniotic fluid drawn from pregnant women during a procedure called amniocentesis. During this test, a doctor inserts a long, thin needle into a pregnant woman's abdomen to collect amniotic fluid. The fluid can be tested for abnormalities, such as Down syndrome, and fetal maturity. The procedure is generally considered safe for the developing fetus and the mother. More study of amniotic fluid stem cells is needed to understand their potential.

Wednesday, November 10. 2010

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Wednesday, November 10. 2010

New at Forever Young, Inc: Stem cell Therapy.

New at Forever Young, Inc.

Stem cell therapy. I started my training at UCLA as an Immunologist and Microbiologist and have discussed the potential benefits of stem cell therapy in the past.

I had to do a lot of research and make sure the science behind using stem cell therapy in cosmetic surgery was sound. I had used PRP (Plasma Rich Protein) over 12 years ago in my cosmetic fellowship program. The results were good but the procedure was cumbersome and expensive. Well; the science has improved and the cost has come down drastically.

Starting this month we will merge stem cell therapy with a variety of procedures that we already do:

Stem Cell Fat Transfer

Stem Cell Face and Brow Lift

Stem Cell Body Rejuvenation

I will start posting several articles on uses of Stem Cells and PRP in sports medicine, general surgery, and cosmetic surgery.

I believe that stem cell therapy will be the driving force of much scientific advancement in the next decade.

A. David Rahimi, MD, FAAD, FAACS.

Thursday, November 4. 2010

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Thursday, November 4. 2010

The art of Subcision and punch excision!

Lasers and chemical peels, in skilled hands, help improve the appearance of acne scarring. Some patients with deeper ice-pick and rolling scars need a more tailored approach. Lasers and peels alone are simply not enough.

Subcision with a No-Kor needle can make all the difference. The needle has a small sharp scalpel like tip that goes under the rolling scars and cuts the fibrous bands. This, in turn, causes bleeding into these newly created spaces. The trauma and the blood causes collagen synthesis and significant improvement of the scars.

Deeper scars need to simply be cut with a round scalpel called a “punch”. These punches come in various sizes: 1mm, 1.5mm, 2.0mm, etc. After the application of the laser I look at the skin with a strong light at an acute angle. This allows me to see the areas that need more attention. Subcision is performed and deeper scars are excised with the punch and sutured.

Even deep acne scarring can be improved by 40-50 percent this way. A touch up treatments a few months later can increase the improvement to 70-80 percent.

Click on this link and then click on the clinical photographs:

Set 7, 8, and 9 show before and afters of a young patient with deep acne scarring.

http://www.foreveryoung.net/mixto-fractional-co2-laser.html

We hope to see you soon for a free consultation.

A. David Rahimi, MD, FAAD, FAACS.

 

 

Category

Thursday, November 4. 2010

Nail Fungus Treatment with the Cooltouch Laser.

How does the laser work?

The Cool Breeze Laser by the Cool Touch Laser Company kills the fungal organisms and spores that live in and under the toenail. The laser is FDA cleared and approved for this particular use.  The laser light passes through the toenail without causing damage to the nail or the surrounding skin.  The Cool Touch Laser uses instantaneous temperature monitoring to ensure safe treatment of the nail with minimal discomfort.

It will take time for the previously infected nail to grow out and for the new nail to form.  This can take 6 to 12 months depending on the rate of growth of the toenail.

How is the procedure performed? Is there any preparation?  Any Discomfort?

During the first treatment session the nails are filed down with a Diamond Dermabrader to debride the dead skin and prepare the nail. A thin layer of topical anesthesia is applied to numb the skin around the nail plate. The procedure takes 20-30 minutes to perform and involves mild discomfort from heat.

The Cool Breeze Laser is applied by the doctor to cover the entire nail.  When the appropriate temperature is reached a burst of Cryogen is released to cool the nail and stop the heating of the toenail.  Patients are able to resume their regular activities right after the procedure. 

Will the fungus (Onychomycosis) come back?

The cure rate is 70 to 80 percent.  These rates are comparable to aggressive treatment with the oral medications such as Sporonox and Lamisil. Some individuals have a tendency to re-infection with the fungal organisms. A triple strength topical anti-fungal lotion is applied once or twice a week to prevent re infections.

Laser toenail treatment is not covered by insurance.

Click on this link, or cut and paste in your browser, to look at before and after photos.

http://www.cooltouch.com/laser_treatment_for_toenail_fungus_before_and_after_photos.aspx

Please call me if you have any questions:

Zonya V.

Office manager

323 653-7700

Category

Thursday, November 4. 2010

How Pulled is PULLED

 

Aesthetic cosmetic surgery is performed to restore “the youthful look”. We all can agree that some celebrities just go too far. Bruce Jenner, Heidi Montag, Donatella Versace, Jocelin Wildenstein, and Amanda Leopre are great examples.

 

I looked at their before and after photos on several popular sites and asked myself: How could this happen? These are intelligent, articulate people with the means to see very skilled cosmetic doctors! Are they aware that they looked better before their obsession with Cosmetic Surgery forever changed their faces?

I believe the problem is complex. Childhood insecurities, doctors that cannot say NO, and loved ones who don’t intervene are some of the factors.  We (the public) probably make things worse by giving them even more attention.

Body dysmorphic syndrome is a pervasive problem. These celebrities represent extreme cases. I deal routinely in my practice with patients who have either unrealistic expectations or want a certain a look that I cannot provide. I politely say NO; discourage them from having “cutting” surgery and urge them to find ways to reduce stress in their lives. I do provide them with a sound, effective, and safe facial treatment regimen that promote Collagen synthesis and improves their skin tone.

“Less is more” echoes out of the examining room into the hallways. Most move on to find another practitioner that will provide them with what they need. Some realize my genuine interest in helping them look better without drastic surgery.

A. David Rahimi,MD,FAAD,FAACS.

Category

Thursday, November 4. 2010

Surgical versus Nonsurgical Rejuvenation

You have a choice. Almost everything aesthetic about the face can be performed surgically versus nonsurgical!

·         Eyelid Surgery: Blepharoplasty versus Thermacool/Cooltouch laser/Botox/Dysport

·         Facelift:               Rhytidectomy versus Thermacool/Cooltouch/Fillers such as Radiesse/Juvederm, fat transfer, Mixto CO2 laser.

·         Cheek Implants: Silicone Implant versus fat transfer, Radiesse, Juvederm.

·         Forehead lift:    Endoscopic Lift versus Volume replacement with fat, Thermacool

·         Liposuction:       Coollipo (laser liposuction) versus Coolsculpting (freeze the fat)

·         Wrinkles:            Surgical facelift versus CO2 Mixto Fraxel, chemical peels, filler, fat transfer

We will tailor a treatment that fits your desires, lifestyle and budget. Most of our treatments have minimal to no-down time.

We hope to see you soon for a complimentary consultation.

Thank you.

Zonya Vialltoro

Office manager

Forever Young, Inc.

Tel 323 653-7700

Wednesday, November 3. 2010

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Wednesday, November 3. 2010

Human Embryonic Fibroblasts stem cells improve sun damaged skin

 A recent article in Dermatology Times by Louise Gagnon was quite interesting and worth sharing with you. The article appeared in the October 2010 issue of dermatology Times pages 60-62.

The article starts by pointing out that “Growth factors that are developed via human fibroblast stem cells hold promise of skin rejuvenation without risk of toxicity or infection”. The article elaborates all the uses of human embryonic fibroblast stem cells and shows actual before and after photos that show quite drastic improvement in the cell texture, color, and tightness.

I received my BS from UCLA in Microbiology and had a special interest in immunology.

I believe this is the “future” of facial rejuvenation.

Here is another older article abstract by Dr Gold.

Human growth factor and cytokine skin cream for facial skin rejuvenation as assessed by 3D in vivo optical skin imaging

Journal of Drugs in Dermatology, Oct, 2007 by Michael H. Gold, Mitchel P. Goldman, Julie Biron

 

Growth factors, in addition to their crucial role in cutaneous wound healing, are also beneficial for skin rejuvenation. Due to their multifunctional activities such as promoting skin cell proliferation and stimulating collagen formation, growth factors may participate in skin rejuvenation at various levels. The present placebo-controlled study aimed to further investigate the antiaging effects of a novel skin cream containing a mixture of human growth factors and cytokines, which was obtained through a biotechnology process using cultured human fetal fibroblasts. Aside from clinical assessment of skin wrinkles, the skin surface topography was analyzed by 3D in vivo optical skin imaging using the Phaseshift Rapid in vivo Measurement of Skin (PRIMOS) device. This device allows fast, contact-free, and direct measurement of the skin surface topography in vivo at high resolution. This technique is quantitative and more reliable than a visual assessment of wrinkles using a scoring system, which is subjective and strongly dependent on investigator and assessment conditions. Using the PRIMOS device, which is also regarded as a more accurate method than the commonly used silicon replica technique, skin surface roughness was shown to significantly decrease between 10% and 18% depending on the roughness parameter after 2 months of twice-daily application of the human growth factor and cytokine cream. This was compared to treatment with the placebo formulation resulting in an approximate 10% decrease of 2 roughness parameters, whereas the remaining parameters remained unchanged. We found that topical application of growth factors and cytokines are beneficial in reducing signs of skin aging.

 

Tuesday, November 2. 2010

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Tuesday, November 2. 2010

Drinking Green Tea can help prevent Skin Cancer

I recently read an article in the October issue of the Cosmetic Dermatology Journal that might interest you. I believe the title is self explanatory:

Green Tea and its Photoprotective and Anticarcinogenic Effects on the Skin. This article was written by Matthew Zarraga D.O. and David Judy, D.O.

Vol 23 No.10 October 2010 pages 446-449

www.cosderm.com

The article starts by mentioning that Tea is the most commonly consumed beverage in the world. It continues to details it’s in vivo and in-vitro photo protective and anti-carcinogenic effects.  It concludes by saying that: both oral consumption and topical application of green tea can provide both chemoprotection and photoprotection”.

Look for products with green tea extract in them and try Trader Joe' Green Tea!

Asian countries that consume more green tea are known to have lower risks for many types of cancers. On a personal note: I stopped consuming carbonated drinks a while back. Plenty of water, 2 cups of coffee, and one or two cups of green tea at night have made a big difference in the way I feel.

A. David Rahimi, MD, FAAD,FAACS.